PUBLICATIONS
Kevin's Google Scholar profile
2026
37. Sharin, M. D.; Fitzgerald, N. J.; Kennedy, S. M.; Park, I. G.; Clark, K. D. “Enzymatic Ligation Strategy to Enhance Electrospray Ionization Efficiency and Liquid Chromatography-Mass Spectrometry of DNA and RNA Oligonucleotides” Under review, 2026, preprint available on bioRxiv: https://doi.org/10.64898/2026.04.09.717506
36. Huang, H-X.; Floro, G. M.; Asare, E.; Huang, W.; Clark, K. D. "Neuronal tRNA Modifications in Aplysia californica are Repatterned during Behavioral Habituation" In revision. preprint available on bioRxiv, https://doi.org/10.1101/2025.11.13.688303
35. Floro, G. M.; McCarragher, C. P.; Shih, Y-L.; Clark, K. D. "Selective Preconcentration and Mass Spectrometry Profiling of Charged Extracellular Modified Ribonucleosides by Borate Complexation, Temperature-Assisted Ionic Liquid Microextraction" ACS Meas. Sci. Au. Accepted.
34. Fitzgerald, N. J.; Huang, W.; Clark, K. D. "RNA Sample Preparation Strategies for Mass Spectrometry Sequencing of the Epitranscriptome and Therapeutic RNAs" Anal. Chim. Acta, 2026, 1393, 345154
2023
33. Sharin, M. D.†; Floro, G. M.†; Clark, K. D. “Advances in Nucleic Acid Sample Preparation for Electrospray Ionization and Matrix-Assisted Laser Desorption Ionization Mass Spectrometry” Int. J. Mass Spectrom. 2023, 494, 117138. (†Authors contributed equally to this work).
32. Patel, A. and Clark, K. D. "Characterizing RNA Modifications in the Central Nervous System and Single Cells by RNA Sequencing and Liquid Chromatography-Tandem Mass Spectrometry Techniques" Anal. Bioanal. Chem. 2023, 415, 3739–3748.
Prior to Tufts University
2022
31. Melzer, M. E.; Sweedler, J. V.; Clark, K. D. “Rapid Determination of RNA Modifications in Consensus Motifs by Nuclease Protection with Ion-Tagged Oligonucleotide Probes and Matrix-Assisted Laser Desorption Ionization Mass Spectrometry” Genes 2022, 13, 1008.
30. Clark, K. D. “Sample Preparation Strategies for Characterizing RNA Modifications in Small-Volume Samples and Single Cells” LCGC North America, 2022, 40, 270–273.
29. Clark, K. D.; Rubakhin, S. S.; Sweedler, J. V. “Characterizing RNA Modifications in Single Neurons using Mass Spectrometry” J. Vis. Exp. JoVE 2022, 182, 63940.
2021
28. Clark, K. D.; Rubakhin, S. S.; Sweedler, J. V. “Single Neuron RNA Modification Analysis by Mass Spectrometry: Characterizing RNA Modification Patterns and Dynamics with Single-Cell Resolution” Anal. Chem. 2021, 93, 14537–14544.
27. Clark, K. D.; Lee, C.; Gillette, R. G.; Sweedler, J. V. “Characterization of Neuronal RNA Modifications during Non-Associative Learning in Aplysia Reveals Key Roles for tRNAs in Behavioral Sensitization” ACS Cent. Sci. 2021, 7, 1183–1190.
2020
26. Clark, K. D.; Philip, M. C.; Tan. Y.; Sweedler, J. V. “Biphasic Liquid Microjunction Extraction for Profiling Neuronal RNA Modifications by Liquid Chromatography−Tandem Mass Spectrometry” Anal. Chem. 2020, 92, 12647–12655.
2019
25. Clark, K. D.; Zhu, C.; Anderson, J. L. “Maximizing Ion-tagged Oligonucleotide Loading on Magnetic Ionic Liquid Supports for the Sequence-Specific Extraction of Nucleic Acids” Anal. Chem. 2019, 91, 5945-5952.
24. Hice, S. A.*; Clark, K. D.*; Anderson, J. L.; Brehm-Stecher, B. F. “Capture, Concentration, and Detection of Salmonella in Foods using Magnetic Ionic Liquids and Recombinase Polymerase Amplification” Anal. Chem. 2019, 91, 1113–1120. *Authors contributed equally to this work.
23. Ding, X.; Clark, K. D.; Varona, M.; Emaus, M. N.; Anderson, J. L. “Magnetic Ionic Liquid-Enhanced Isothermal Nucleic Acid Amplification and its Application to Rapid Visual DNA Analysis” Anal. Chim. Acta 2019, 1045, 132-140.
2018
22. Santra, K.; Clark, K. D.; Maity, N.; Petrich, J. W.; Anderson, J. L. “Exploiting Fluorescence Spectroscopy to Identify Magnetic Ionic Liquids Suitable for the Isolation of Oligonucleotides” J. Phys. Chem. B 2018, 122, 7747-7756.
21. Varona, M.; Ding, X.; Clark, K. D.; Anderson, J. L. “Solid-Phase Microextraction of DNA from Mycobacteria in Artificial Sputum Samples to Enable Visual Detection using Isothermal Amplification” Anal. Chem. 2018, 90, 6922-6928.
20. Anderson, J. L.; Clark, K. D. “Ionic Liquids as Tunable Materials in (Bio)Analytical Chemistry” Anal. Bioanal. Chem. 2018, 410, 4565-4566.
19. Emaus, M. N.; Clark, K. D.; Hinners, P.; Anderson, J. L. “Preconcentration of DNA using Magnetic Ionic Liquids that are Compatible with Real-Time PCR for Rapid Nucleic Acid Quantification” Anal. Bioanal. Chem. 2018, 410, 4135–4144.
18. Peng, X.; Clark, K. D.; Ding, X.; Zhu, C.; Varona, M.; Emaus, M. N.; An, J.; Anderson, J. L. “Coupling Oligonucleotides Possessing a Poly-Cytosine Tag with Magnetic Ionic Liquids for Sequence-Specific DNA Analysis” Chem. Commun. 2018, 73, 10284-10287.
17. Clark, K. D.; Trujillo-Rodríguez, M. J.; Anderson, J. L. “Advances in the Analysis of Biological Samples using Ionic Liquids” Anal. Bioanal. Chem. 2018, 410, 4567–4573.
16. Clark, K. D.; Emaus, M. N.; Varona, M.; Bowers, A. N.; Anderson J. L. “Ionic Liquids: Solvents and Sorbents in Sample Preparation” J. Sep. Sci. 2018, 41, 209-235.
2017
15. Nacham, O.; Clark, K. D.; Varona, M.; Anderson, J. L. “Selective and Efficient RNA Analysis by Solid-Phase Microextraction” Anal. Chem. 2017, 89, 10661-10666.
14. Clark, K. D.; Varona, M.; Anderson, J. L. “Ion-Tagged Oligonucleotides Coupled with a Magnetic Liquid Support for the Sequence-Specific Capture of DNA” Angew. Chem. Int. Ed. 2017, 56, 7630-7633.
13. Clark, K. D.; Purslow, J. A.; Pierson, S. A.; Nacham, O.; Anderson, J. L. “Rapid Preconcentration of Viable Bacteria using Magnetic Ionic Liquids for PCR Amplification and Culture-based Diagnostics” Anal. Bioanal. Chem. 2017, 409, 4983-4991.
12. Pierson, S. A.; Nacham, O.; Clark, K. D.; Nan, H.; Mudryk, Y. Anderson, J. L. “Synthesis and Characterization of Low Viscosity Hexafluoroacetylacetonate-based Magnetic Ionic Liquids” New J. Chem. 2017, 41, 5498-5505.
2016
11. Clark, K. D.; Zhang, C.; Anderson, J. L. “Sample Preparation for Bioanalytical and Pharmaceutical Analysis” Anal. Chem. 2016, 88, 11262-11270.
10. Nacham, O.; Clark, K. D.; Anderson, J. L. “Extraction and Purification of DNA from Complex Biological Sample Matrices using Solid-Phase Microextraction Coupled with Real-Time PCR” Anal. Chem. 2016, 88, 7813-7820.
9. Trujillo-Rodriguez, M. J.; Nacham, O.; Clark, K. D.; Pino, V.; Anderson, J. L.; Ayala, J. H.; Afonso, A. M. “Magnetic Ionic Liquids as Non-conventional Extraction Solvents for the Determination of Polycyclic Aromatic Hydrocarbons” Anal. Chim. Acta 2016, 934, 106-113.
8. Clark, K. D.; Nacham, O.; Purslow, J. A.; Pierson, S. A.; Anderson, J. L. “Magnetic Ionic Liquids in Analytical Chemistry: A Review” Anal. Chim. Acta 2016, 934, 9-21.
7. Clark, K. D.; Sorensen, M.; Nacham, O.; Anderson, J. L. “Preservation of DNA in Nuclease-Rich Samples using Magnetic Ionic Liquids” RSC Adv. 2016, 6, 39846-39851.
6. Nacham, O.; Clark, K. D.; Anderson, J. L. “Synthesis and Characterization of the Physicochemical and Magnetic Properties for Perfluoroalkyl Ester and Fe(III) Carboxylate-based Hydrophobic Magnetic Ionic Liquids” RSC Adv. 2016, 6, 11109-11117.
2015
5. Clark, K. D.; Yamsek, M. M.; Nacham, O.; Anderson, J. L. “Magnetic Ionic Liquids as PCR-compatible Solvents for DNA Extraction from Biological Samples” Chem. Commun. 2015, 51, 16771-16773.
4. Yu, H.; Clark, K. D.; Anderson, J. L. “Rapid and Sensitive Analysis of Microcystins using Ionic Liquid-based in situ Dispersive Liquid-Liquid Microextraction” J. Chromatogr. A 2015, 1406, 10-18.
3. Nacham, O.; Clark, K. D.; Anderson, J. L. “Analysis of Bacterial Plasmid DNA by Solid-Phase Microextraction” Anal. Methods 2015, 7, 7202-7207.
2. Clark, K. D.; Nacham, O.; Yu, H.; Li, T.; Yamsek, M. M.; Ronning, D. R.; Anderson, J. L. “Extraction of DNA by Magnetic Ionic Liquids: Tunable Solvents for Rapid and Selective DNA Analysis” Anal. Chem. 2015, 87, 1552-1559.
1. Nacham, O.; Clark, K. D.; Yu, H.; Anderson, J. L. “Synthetic Strategies for Tailoring the Physicochemical and Magnetic Properties of Hydrophobic Magnetic Ionic Liquids” Chem. Mater. 2015, 27, 923-931.